منابع مشابه
Nitric oxide and cyclic nucleotides
Spermatogenesis is a highly complicated process in which functional spermatozoa (haploid, 1n) are generated from primitive mitotic spermatogonia (diploid, 2n). This process involves the differentiation and transformation of several types of germ cells as spermatocytes and spermatids undergo meiosis and differentiation. Due to its sophistication and complexity, testis possesses intrinsic mechani...
متن کاملRadioimmunoassay for Cyclic Nucleotides
Sensitive and specific radioimmunoassays have been developed for cyclic adenosine 3’, 5’-monophosphate (CAMP), cyclic guanosine 3’ ,5’-monophosphate (cGMP), cyclic inosine 3’ ,5’-monophosphate (cIMP), and cyclic uridine 3’, 5’monophosphate (cUMP). These assays are based upon competition of the cyclic nucleotide with isotopically labeled cyclic nucleotide derivatives for binding sites on specifi...
متن کاملCyclic nucleotides and phosphodiesterases and airway function.
The cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) play an important role in the regulation of airway smooth muscle tone and activation of inflammatory cells. Intracellular concentrations of these nucleotides are tightly regulated by phosphodiesterases (PDEs). Several families of PDEs are now recognized and, within each isoenzyme family, mole...
متن کاملCyclic Nucleotides Attenuate Thrombin-evoked Alterations
In this work, we explored the role of cyclic nucleotides in modulating parameters of the Na/H antiport in human platelets. Sodium nitroprusside and iloprost, as well as cyclic nucleotide analogues, were used to raise cellular levels of cAMP and cGMP. Cyclic nucleotides reversed the thrombin-evoked alkaline shift in cytosolic pH set point and the activity of the Na/H antiport, concurrently with ...
متن کاملOrnithine decarboxylase activity: control by cyclic nucleotides.
Both exposure to cold and administration of aminophylline result in rapid increases in cyclic adenosine monophosphate (cyclic AMP) in the adrenal medulla and adrenal cortex. These increases are followed by dramatic increases in ornithine decarboxylase activity is due to new enzyme systhesis. The data suggest that the decarboxylase activity is regulated by an increase in cyclic AMP.
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/256008a0